Johnny Sexton and Peter O'Mahony are sidelined this weekend due to injury
The two have been ruled out of their Six Nations opener with Scotland on Saturday.
The fly-half is sidelined with a calf injury, while the back-row-forward has a hamstring problem.
Speaking at the tournament's launch, captain Rory Best says there's a great attitude among the squad's seasoned campaigners.
Ireland 6 Nations fixtures (Times in GMT):
Scotland v Ireland Murrayfield February 4th 14:25
Italy v Ireland Stadio Olimpico February 11th 14:25
Ireland v France Aviva Stadium February 25th 16:50
Wales v Ireland Principality Stadium March 10th 20:00
Ireland v England Aviva Stadium March 18th 17:00